[Cryptococcosis of the CNS]

The findings and opinions which are of greater importance for clinical practice with respect to the etiopathogenesis, epidemiology, symptomatology, diagnostics and therapy of cryptococcosis of the central nervous system are discussed with special consideration of the cerebrospinal fluid findings and in evaluation of two cases treated by the authors. Crytococcosis of the CNS produces no clinical pictures that are only typical of it. Favourable curing changes, however, only exist if a specific therapy is initiated systematically and at an early time, for which the application of a combination of amphotericin B and 5-fluorocytosin is considered as the therapy of first choice today. Hints are given that should make an inclusion of cryptococcosis in the differential-diagnostic consideration possible.