Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Erythrocyte deformability in a red cell ageing model

H Leonhardt, H G Grigoleit, I Reinhardt

    La Ricerca in Clinica E in Laboratorio
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Long-term outcomes of open treatment of condylar head fractures using cannulated headless bone screws-a retrospective analysis.

    International journal of oral and maxillofacial surgery·2025
    Same author

    Adapter CAR T cells to counteract T-cell exhaustion and enable flexible targeting in AML.

    Leukemia·2023
    Same author

    Accuracy of transvaginal ultrasound versus MRI in the PreOperative Diagnostics of low-grade Endometrial Cancer (PODEC) study: a prospective multicentre study.

    Clinical radiology·2022
    Same author

    Clinical experience and results with a Rhombic Plate for transoral endoscopically-assisted osteosynthesis of fractures of the condylar neck.

    The British journal of oral & maxillofacial surgery·2019
    Same author

    New method of alloplastic reconstruction of the mandible after subtotal mandibulectomy for medication-related osteonecrosis of the jaw.

    The British journal of oral & maxillofacial surgery·2018
    Same author

    Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia.

    Leukemia·2017

    Pentoxifylline significantly improves erythrocyte deformability in aged blood, while theophylline shows a minor effect and prednisolone has no significant impact. This study highlights pentoxifylline

    Area of Science:

    • Hematology
    • Pharmacology

    Background:

    • Erythrocyte deformability decreases over time during blood storage.
    • Ageing red blood cells exhibit reduced deformability, impacting microcirculation.

    Purpose of the Study:

    • To investigate the dose-dependent effect of pentoxifylline on erythrocyte deformability in ageing blood.
    • To compare the effects of theophylline and prednisolone on erythrocyte deformability.

    Main Methods:

    • Blood samples from healthy subjects were stored to induce ageing.
    • Erythrocyte deformability was measured after incubation with varying doses of pentoxifylline, theophylline, and prednisolone.
    • Control groups were used for comparison.

    Main Results:

    • Pentoxifylline demonstrated a dose-dependent increase in erythrocyte deformability, observable immediately after administration.

    Related Experiment Videos

  • Theophylline showed a slight increase in erythrocyte deformability, not statistically significant compared to controls.
  • Prednisolone caused a minor reduction in erythrocyte deformability, also not statistically significant.

    • Conclusions:

    • Pentoxifylline effectively enhances erythrocyte deformability in ageing red blood cells.
    • Theophylline and prednisolone do not significantly alter erythrocyte deformability in this context.
    • None of the tested substances affected the rate of red blood cell ageing.