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Sperm immobilization by dental focus microorganisms

A Linossier, A Thumann, E Bustos-Obregon

    Andrologia
    |May 1, 1982
    PubMed

    Insights

    Focal infections from Escherichia coli can negatively impact male fertility. Bacterial filtrate from dental infections was found to significantly reduce human sperm motility in vitro.

    Area of Science:

    • Microbiology
    • Reproductive Biology
    • Toxicology

    Background:

    • Focal infections are suspected to cause systemic effects, but their impact on reproductive tissues remains debated.
    • Open pulpar necrosis, often caused by bacteria like Escherichia coli, represents a potential source of focal infection.

    Purpose of the Study:

    • To investigate the in vitro effect of Escherichia coli filtrate from open pulpar necrosis on human sperm motility.
    • To characterize the factor responsible for sperm immobilization.

    Main Methods:

    • Preparation of filtrate from Escherichia coli isolated from open pulpar necrosis.
    • In vitro assessment of the filtrate's effect on human sperm motility.
    • Characterization of the immobilizing factor through heat, lyophilization, and dialysis.

    Main Results:

    • Escherichia coli filtrate significantly reduced human sperm motility.
    • The immobilizing factor was found to be heat-stable.
    • The factor was resistant to lyophilization and non-dializable.

    Conclusions:

    • A substance produced by Escherichia coli in open pulpar necrosis can impair sperm motility.
    • This immobilizing factor may reach the male reproductive system via the bloodstream.
    • Focal dental infections could potentially contribute to male infertility.

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