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[Antimycotic sensitivities of the clinically isolated candidas]
Abstract:
82 candida strains isolated from clinical material were tested for their sensitivity to nystatin, 5-fluorocytosine (5-FC) and to clotrimazole. Strains were showing high M.I.C. values against nystatin and 45% primary resistance to 5-FC by the tube dilution technique. No resistance was noted to clotrimazole. The resistance, developed in candida strains against several antifungal drugs, will establish the problem encountered in the antibiotic treatment of bacterial infections. Also the necessity of the sensitivity tests with the isolated candida strains in candida infections is emphasized.
Insights
This study found that many Candida strains exhibit resistance to common antifungal drugs like nystatin and 5-fluorocytosine (5-FC). However, clotrimazole remained effective against all tested strains, highlighting the need for antifungal sensitivity testing in clinical settings.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Clinical Microbiology
Background:
- Candida species are common opportunistic pathogens causing infections, particularly in immunocompromised individuals.
- Antifungal drug resistance is a growing concern, complicating treatment strategies for candidiasis.
- Understanding the susceptibility patterns of clinical Candida isolates is crucial for effective therapeutic selection.
Purpose of the Study:
- To evaluate the in vitro susceptibility of clinical Candida isolates to three antifungal agents: nystatin, 5-fluorocytosine (5-FC), and clotrimazole.
- To identify the prevalence of primary resistance to these antifungal drugs among the tested Candida strains.
- To emphasize the importance of antifungal sensitivity testing in managing Candida infections.
Main Methods:
- Isolation and identification of 82 Candida strains from various clinical specimens.
- Determination of Minimum Inhibitory Concentrations (MICs) using the tube dilution technique.
- Testing susceptibility against nystatin, 5-fluorocytosine (5-FC), and clotrimazole.
Main Results:
- A significant proportion of Candida strains displayed high MIC values for nystatin.
- Primary resistance to 5-fluorocytosine (5-FC) was observed in 45% of the isolates.
- No resistance to clotrimazole was detected among any of the tested Candida strains.
Conclusions:
- The emergence of antifungal resistance in Candida strains poses a significant challenge in treating infections.
- Clotrimazole demonstrates potent in vitro activity against the studied clinical isolates.
- Routine antifungal susceptibility testing is essential for guiding appropriate therapy in patients with candidiasis.