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Considerations in receiving and quarantining laboratory rodents

F M Loew

    Laboratory Animal Science
    |April 1, 1980
    PubMed
    Summary

    Increased pathogen detection in research animals presents a quarantine dilemma due to high costs and new regulations. Laboratory animal medicine specialists must use professional judgment to balance animal quality with research needs, implementing quarantine only when truly appropriate.

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    Area of Science:

    • Laboratory animal science
    • Veterinary pathology
    • Biomedical research

    Background:

    • Advanced bacteriologic and viral screening reveals pathogen exposure in research animals, even from reputable suppliers.
    • The high financial and spatial costs of universal rodent quarantine pose a significant challenge for research institutions.
    • Evolving regulations increasingly mandate quarantine periods for laboratory animals.

    Purpose of the Study:

    • To address the dilemma between increased pathogen detection and the costs/regulations associated with animal quarantine.
    • To highlight the critical role of expert judgment in determining appropriate quarantine strategies.
    • To propose a balanced approach for managing research animal health and research integrity.

    Main Methods:

    • Review of current practices in animal screening and quarantine.
    • Analysis of the impact of regulations on research institutions.
    • Emphasis on the application of professional judgment by laboratory animal medicine specialists.

    Main Results:

    • Enhanced screening identifies potential pathogens, creating a need for risk assessment.
    • The cost-benefit analysis of universal quarantine is often unfavorable.
    • Regulatory mandates for quarantine are increasing, irrespective of demonstrated need.

    Conclusions:

    • A pragmatic approach involves matching animal quality with specific research requirements.
    • Quarantine should be implemented judiciously based on risk assessment and professional evaluation.
    • Expert judgment is essential for navigating the complexities of research animal health management.

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