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Behavioral thermoregulation in rats during hyperthermia induced by lysergic acid diethylamide
Neuroscience Letters
|October 20, 1980
Abstract:
In free moving rats trained to press a bar to escape from radiant heat, lysergic acid diethylamide (LSD, 8-16 micrograms) produced a significant and dose-dependent increase of the bar-pressing rate when injected intraperitoneally. During the increase in the bar-pressing rate, the rectal temperature showed an increase and both the tail-skin and the ambient temperature selected decreased concomitantly. The results indicate that LSD-induced hyperthermia is not due to an upward setting of the thermostat but mediated through the action of LSD on the effector pathways in the rats.