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Surgery in patients with hepatitis

S Giller, S Berliner, Y Shoenfeld

    Medecine Interne
    |April 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Major surgeries for hepatitis patients showed high mortality, particularly with acute yellow atrophy and septic shock. Corticosteroid treatment improved outcomes for chronic active hepatitis patients.

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    Area of Science:

    • Hepatology
    • Surgical Outcomes
    • Liver Disease Management

    Background:

    • Hepatitis presents diverse clinical challenges, impacting surgical candidacy and outcomes.
    • Major surgical interventions in patients with liver disease carry significant risks.
    • Understanding the role of comorbidities like malignancy in hepatitis is crucial.

    Purpose of the Study:

    • To review surgical outcomes in patients with various forms of hepatitis.
    • To evaluate the impact of associated conditions on mortality after surgery.
    • To assess the efficacy of corticosteroid treatment in chronic active hepatitis patients undergoing surgery.

    Main Methods:

    • Retrospective review of thirteen major operations in twelve hepatitis patients.
    • Analysis of mortality causes, including acute yellow atrophy and septic shock.

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  • Comparison of outcomes between hepatitis patients with and without corticosteroid treatment.

    • Main Results:

    • Five out of twelve patients died post-surgery, with four deaths attributed to acute yellow atrophy and one to septic shock.
    • Malignancy was implicated as a contributing factor in deaths among acute viral hepatitis patients.
    • One patient with chronic active hepatitis on corticosteroids recovered uneventfully, while two not on corticosteroids died from hepatic failure.

    Conclusions:

    • Surgical interventions in hepatitis patients are associated with high mortality, especially in cases of acute yellow atrophy and septic shock.
    • Associated malignancy may worsen outcomes in acute viral hepatitis.
    • Corticosteroid therapy appears beneficial for chronic active hepatitis patients undergoing surgery, potentially reducing hepatic failure risk.