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Dengue with haemorrhage and shock in Jakarta, Indonesia
Insights
A 1973-1974 Jakarta study found dengue virus in 81 pediatric patients with fever and hemorrhage. This research highlights the significant presence and impact of dengue hemorrhagic fever in Indonesian children.
Area of Science:
- Virology
- Pediatrics
- Epidemiology
Background:
- Dengue hemorrhagic fever (DHF) is a significant public health concern, particularly in tropical regions.
- Early studies are crucial for understanding the epidemiology and clinical presentation of emerging infectious diseases.
Purpose of the Study:
- To investigate the occurrence and characteristics of dengue virus infections in pediatric patients presenting with fever and hemorrhage in Jakarta, Indonesia.
- To compare clinical findings with those previously reported in Thailand.
Main Methods:
- Clinical observation and diagnosis of 104 pediatric patients presenting with fever and hemorrhage.
- Serological testing using hemagglutination-inhibition and plaque reduction neutralization tests to measure dengue virus antibody titers.
- Isolation of dengue virus serotypes from affected patients.
Main Results:
- Eighty-one out of 104 patients (77.9%) showed clear evidence of dengue infection.
- Clinical manifestations were consistent with those described for dengue hemorrhagic fever in Thailand.
- High antibody titers against dengue were prevalent, and all four dengue virus serotypes were isolated.
- Eight pediatric patients (9.9%) succumbed to the illness.
Conclusions:
- Dengue virus infection, including dengue hemorrhagic fever, was demonstrably present and severe in pediatric populations in Jakarta during the study period.
- The findings underscore the need for robust surveillance and control strategies for dengue in Indonesia.
Abstract:
Pediatric patients with fever and haemorrhage were studied in Jakarta, Indonesia between May 1973 and January 1974. Eighty-one of 104 demonstrated unequivocable evidence of dengue with clinical findings similar to those reported associated with dengue haemorrhagic fever in Thailand. The majority of patients had extremely high antibody titers against dengue measured by both hemagglutination-inhibition and by plaque reduction neutralization tests and all four types of dengue virus were isolated. Eight of the patients died.