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Predictability of immunologic phenotype by morphologic criteria in diffuse aggressive non-Hodgkin's lymphomas
American Journal of Clinical Pathology
|January 1, 1982
Summary
Histologic classification of diffuse aggressive non-Hodgkin's lymphomas is challenging. Morphologic features alone are not always reliable for predicting immunologic cell markers, impacting accurate diagnosis.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Diffuse aggressive non-Hodgkin's lymphomas (NHL) exhibit significant heterogeneity.
- Morphologic subclassifications are proposed to correlate with immunologic phenotypes.
Purpose of the Study:
- To evaluate the reliability of morphologic subclassifications in predicting immunologic phenotypes of diffuse aggressive NHL.
- To assess the accuracy of histopathology in distinguishing between B-cell and T-cell lymphomas.
Main Methods:
- Six histologic types of diffuse aggressive NHL were studied.
- Morphologic features were analyzed and correlated with immunologic surface markers (B-cell, T-cell, histiocytic).
Main Results:
- Follicular subtypes like large non-cleaved and blastic lymphomas showed frequent B-cell markers.
- T-cell lymphomas were sometimes misclassified as follicular center cell types due to overlapping morphology.
- Pleomorphic pyroninophilic morphology was inconsistently associated with B-cell markers, suggesting a common pathway for transformed lymphoid cells.
- Histopathologic subclassification predicted immunologic phenotype in only 61% of cases.
Conclusions:
- Histologic appearance alone is often insufficient for accurately determining the immunologic phenotype in diffuse aggressive NHL.
- Morphologic overlap between subtypes complicates diagnosis, highlighting the need for integrated diagnostic approaches.