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Sarcoidosis in young children

S Hetherington

    American Journal of Diseases of Children (1960)
    |January 1, 1982
    PubMed
    Summary

    Pediatric sarcoidosis in young children presents uniquely, often lacking lung issues but featuring uveitis, arthritis, and skin rash. Early treatment with adrenocorticosteroids can manage chronic arthritis and eye involvement.

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    Area of Science:

    • Pediatric Rheumatology
    • Dermatology
    • Ophthalmology

    Background:

    • Sarcoidosis is a multisystem inflammatory disease of unknown cause.
    • While typically affecting adults, sarcoidosis can occur in children, with distinct clinical presentations in younger age groups.

    Observation:

    • A review of 28 reported cases of sarcoidosis in children 4 years or younger reveals unique characteristics.
    • Infants and toddlers with sarcoidosis often present without pulmonary involvement.
    • Predominant symptoms include uveitis, arthritis, and skin rash, differentiating them from older pediatric patients.

    Findings:

    • The disease course in this age group can include chronic arthritis and potential renal complications due to hypercalciuria.
    • Early-onset sarcoidosis in very young children exhibits a distinct clinical phenotype compared to older children.

    Implications:

    • Adrenocorticosteroids show potential efficacy in managing ocular and renal manifestations of pediatric sarcoidosis.
    • Recognizing this distinct presentation is crucial for timely diagnosis and appropriate management in infants and toddlers.

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