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Stored blood platelets and microaggregate formation

J J McNamara, B S Anderson, T Hayashi

    Surgery, Gynecology & Obstetrics
    |October 1, 1978
    PubMed
    Summary
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    Stored blood platelets form spontaneous aggregates within 10 days, differing from adenosine diphosphate-induced platelet aggregation. This indicates declining platelet quality during blood storage.

    Area of Science:

    • Hematology
    • Transfusion Medicine
    • Blood Banking

    Background:

    • Platelet function and morphology degrade during refrigerated storage.
    • Understanding changes in stored platelets is crucial for transfusion efficacy.

    Purpose of the Study:

    • To investigate the structural and functional changes of platelets in stored blood over 21 days.
    • To compare spontaneous platelet aggregates with adenosine diphosphate-induced aggregates.

    Main Methods:

    • Light and electron microscopy were used to examine platelet structure.
    • Platelet aggregation response to adenosine diphosphate was measured.
    • Observations were conducted over 21 days of storage at 4°C.

    Main Results:

    Related Experiment Videos

    • Spontaneous platelet aggregates appeared within 10 days, differing morphologically from adenosine diphosphate-induced aggregates.
    • Spontaneous aggregation correlated with decreased platelet count and normal platelet morphology.
    • Leukocytes were present in spontaneous aggregates and degenerated over time.

    Conclusions:

    • Platelet quality significantly declines during refrigerated storage, evidenced by spontaneous aggregation and leukocyte infiltration.
    • Morphological and functional changes limit the utility of stored platelets beyond 10 days for aggregation responses.