Chemoimmunotherapy for autochthonous acute rat leukemias

Eighty autochthonous acute rat leukemias that had been induced by ethylnitrosourea were used to compare the effect of single-drug therapy with vincristine, doxorubicin, or cytarabine with the effect of combination therapy using these three drugs with or without BCG-Pasteur F. The combination chemotherapy was clearly superior to the single-drug therapy. The best results (survival time; duration of remission) were achieved by vincristine, doxorubicin, and cytarabine plus BCG, although compared to the combinations without BCG, these results were not significant.