Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Focal segmental lupus nephritis

E Grishman, J Churg

    Clinical Nephrology
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Focal segmental lupus nephritis lesions evolve through distinct stages, often healing with steroid treatment. Prognosis is generally good, influenced by lesion severity and associated factors.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Systemic necrotizing vasculitis.

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
    Same author

    The Mesangium of the Renal Glomerulus: Electron Microscopic Studies of Pathologic Alterations.

    The American journal of pathology·2009
    Same author

    [Exposure to asbestos, smoking, and neoplasms. 1967].

    Salud publica de Mexico·2000
    Same author

    Steroids and Churg-Strauss syndrome.

    Lancet (London, England)·1998
    Same author

    Zafirlukast and Churg-Strauss syndrome.

    JAMA·1998
    Same author

    Mesangiolysis: an update.

    American journal of kidney diseases : the official journal of the National Kidney Foundation·1998

    Area of Science:

    • Nephrology
    • Pathology
    • Immunology

    Background:

    • Focal segmental lupus nephritis is a specific form of lupus nephritis.
    • Understanding its histopathology and clinical course is crucial for patient management.

    Purpose of the Study:

    • To correlate histopathologic findings of focal segmental lupus nephritis with clinical outcomes.
    • To elucidate the evolutionary stages of segmental lesions in lupus nephritis.

    Main Methods:

    • Examination of 19 renal biopsies and 1 autopsy using light, electron, and immunofluorescence microscopy.
    • Correlation of histopathologic data with clinical course in patients with a minimum 2-year follow-up.
    • All patients received steroid treatment.

    Main Results:

    Related Experiment Videos

    • Segmental lesions progress from mesangial proliferation to necrosis and collagenous nodules.
    • Electron microscopy revealed electron-dense deposits in necrotic lobules but no wire loop lesions.
    • An 86% survival rate at an average of 6.3 years was observed.
    • Factors influencing prognosis included the number of affected glomeruli, mesangial deposits, and vasculitis.

    Conclusions:

    • The pathogenesis of segmental lesions may differ from diffuse lupus nephritis, representing a localized reaction.
    • Focal segmental lupus nephritis shows a tendency to heal, especially with steroid therapy.
    • Histopathology provides valuable prognostic information for lupus nephritis patients.