Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hereditary elliptocytosis: morphologic abnormalities during acute hepatitis

C H Pui, W Wang, J Wilimas

    Clinical Pediatrics
    |March 1, 1982
    PubMed
    Summary

    Hereditary elliptocytosis patients may experience increased red blood cell breakdown and shape changes during acute hepatitis. This is linked to altered red blood cell membranes and cholesterol distribution.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pre-B-Cell Acute Lymphoblastic Leukemia in Childhood.

    Leukemia & lymphoma·2016
    Same author

    A revised definition for cure of childhood acute lymphoblastic leukemia.

    Leukemia·2014
    Same author

    Successful challenges using native E. coli asparaginase after hypersensitivity reactions to PEGylated E. coli asparaginase.

    Cancer chemotherapy and pharmacology·2014
    Same author

    Calcium and cholecalciferol supplementation provides no added benefit to nutritional counseling to improve bone mineral density in survivors of childhood acute lymphoblastic leukemia (ALL).

    Pediatric blood & cancer·2014
    Same author

    Results of treatment of advanced-stage lymphoblastic lymphoma at St Jude Children's Research Hospital from 1962 to 2002.

    Annals of oncology : official journal of the European Society for Medical Oncology·2013
    Same author

    Cognitive outcomes following contemporary treatment without cranial irradiation for childhood acute lymphoblastic leukemia.

    Journal of the National Cancer Institute·2012

    Area of Science:

    • Hematology
    • Hepatology
    • Cell Biology

    Background:

    • Hereditary elliptocytosis is a genetic blood disorder characterized by oval-shaped red blood cells.
    • Red blood cell membrane defects are central to the pathophysiology of hereditary elliptocytosis.

    Observation:

    • A 10-year-old girl with hereditary elliptocytosis presented with acute hepatitis.
    • During the hepatitis episode, she exhibited a transient increase in hemolysis (red blood cell destruction).
    • Unusual red blood cell morphologic changes were noted in her peripheral blood smear.

    Findings:

    • The observed hemolysis and morphologic changes in elliptocytes suggest a heightened susceptibility during hepatic inflammation.
    • Alterations in red blood cell membrane lipids, including cholesterol distribution, are implicated.
    • Defects in membrane skeletal proteins, a hallmark of hereditary elliptocytosis, likely contribute to these transient changes.

    Implications:

    • This case highlights the potential for acute hepatitis to exacerbate red blood cell abnormalities in hereditary elliptocytosis.
    • Understanding these interactions may inform clinical management and monitoring of patients with co-existing conditions.
    • Further research into red blood cell membrane dynamics under inflammatory stress is warranted.

    Related Experiment Videos