Kinetics of a high dose of piretanide in renal failure

The kinetics of piretanide was studied in patients with renal failure. After oral administration of a high dose of piretanide (96 mg), the pharmacokinetic parameters were: elimination rate constant 0.346 +/- 0.072 h-1, half life 2.00 +/- 0.35 h, and total plasma clearance 119.55 +/- 35.90 ml x min-1. Compared to the values obtained in adults with normal renal function, these results show a decrease in total plasma clearance, but conservation of the metabolic clearance which amounts to 45% of the total clearance in the healthy adult.