Effect of 15(R)-15-methyl-prostaglandin E2 on iron absorption in the rat

The administration of 15(R)-15-methyl prostaglandin E2 (15(R)-15-M-PGE2) in vivo significantly diminished the uptake of (59)Fe into blood, spleen, liver, femur and dried intestine of rats, whereas acetylsalicylic acid (ASA) increased the counts significantly. This effect of ASA was counteracted by 15(R)-15-M-PGE2. It is suggested that prostaglandins (PGs)might play an important role in inhibiting iron absorption at the intestinal level.