[Effect of anabasine hydrochloride on embryogenesis in white rats and rabbits]

The author reports the results of testing the embryotropic activity of anabasineee hydrochloride in doses of 15, 5, and 3 mg/kg. It was found that oral administration of the drug to pregnant rats in doses exceeding 10-fold (5 mg/kg) and 20-fold (10 mg/kg) the therapeutic ones produced no adverse effect on the fetus. In a dose of 15 mg/kg the drug exerted a moderate embryotoxic action. Multiple oral administration of anabasin hydrochloride to rats in a dose of 3 mg/kg produced no embryotoxic effect. It is concluded that anabasin hydrochloride has no teratogenic properties.