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Related Experiment Videos

Liposomes in topical drug delivery

H E Schaeffer, D L Krohn

    Investigative Ophthalmology & Visual Science
    |February 1, 1982
    PubMed
    Summary

    Liposomes enhance topical drug delivery by adsorbing to the cornea and facilitating drug transfer. Positively charged liposomes significantly increase transcorneal drug flux, outperforming traditional methods.

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    Area of Science:

    • Ophthalmology
    • Pharmaceutics
    • Materials Science

    Background:

    • Liposomes are investigated as potential topical drug delivery vehicles.
    • Both water- and lipid-soluble drugs can be encapsulated within liposomes.
    • Corneal drug penetration is a critical factor in topical ophthalmic therapy.

    Purpose of the Study:

    • To evaluate liposomes as topical drug delivery systems for ocular administration.
    • To determine the influence of liposome charge on corneal drug uptake.
    • To compare liposome-mediated drug delivery with conventional methods.

    Main Methods:

    • Liposomes of varying charges (positive, negative, neutral) were prepared.
    • Transcorneal drug flux of penicillin G and indoxole was measured across isolated rabbit cornea.
    • Drug delivery efficiency was compared between liposomes and polysorbate 80 in rat models.

    Main Results:

    • Positively charged liposomes showed greatest corneal uptake due to electrostatic adsorption.
    • Unilamellar liposomes significantly enhanced transcorneal penicillin G flux (over fourfold).
    • Liposomal drug entrapment is essential for enhanced transport; pre-mixed drug showed no improvement.

    Conclusions:

    • Liposomes, particularly positively charged ones, are effective topical drug delivery vehicles for ocular applications.
    • Liposomes enhance corneal penetration by surface adsorption and direct drug transfer to corneal cells.
    • Liposome-mediated delivery is significantly more efficient than polysorbate 80 formulations.

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