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Decrease in canine corneal endothelial cell density and increase in corneal thickness as functions of age

R M Gwin, I Lerner, J K Warren

    Investigative Ophthalmology & Visual Science
    |February 1, 1982
    PubMed
    Summary

    As dogs age, their corneal endothelial cell density decreases and corneal thickness increases. Healthy canine corneal endothelial cells enlarge and migrate, making dogs a good model for future cell studies.

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    Area of Science:

    • Veterinary Ophthalmology
    • Corneal Physiology
    • Comparative Biology

    Background:

    • The canine cornea shares similarities with human corneal endothelium.
    • Understanding age-related changes in canine corneal endothelium is crucial for research.
    • Specular microscopy is a key diagnostic tool in veterinary ophthalmology.

    Purpose of the Study:

    • To investigate the relationship between age and corneal endothelial cell density, morphology, and thickness in dogs.
    • To assess the functional capacity of aging canine corneal endothelium.
    • To evaluate the dog as a model for human corneal endothelial research.

    Main Methods:

    • Contact specular microscopy was performed on 59 normal dogs of varying ages (6 weeks to 132 months).
    • Corneal endothelial cell density and morphology were analyzed.

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  • Corneal thickness was measured.
  • Data were analyzed to determine age-related trends.

    • Main Results:

    • Canine corneal endothelial cells enlarge with age.
    • Cell density decreases significantly in older dogs (below 2100 cells/mm2) compared to younger dogs (around 2500 cells/mm2).
    • Corneal thickness significantly increases with age.

    Conclusions:

    • Healthy canine corneal endothelial cells maintain a functional monolayer through enlargement and migration as they age.
    • Dogs serve as a suitable model for studying corneal endothelial cell behavior and age-related changes.
    • Findings contribute to veterinary ophthalmology and comparative corneal research.