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Related Experiment Videos

Intercellular junctions in the developing arachnoid membrane in the chick

J J Van Rybroek, F N Low

    The Journal of Comparative Neurology
    |January 1, 1982
    PubMed
    Summary
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    Microdissection by ultrasonication: application to early chick embryos.

    Biotechnic & histochemistry : official publication of the Biological Stain Commission·1994

    The arachnoid membrane develops distinct zones and junctional complexes, including desmosomes and gap junctions, during chick embryo development. Tight junctions emerge later, becoming interwoven by hatching, indicating maturation of this crucial brain barrier.

    Area of Science:

    • Developmental Biology
    • Cell Biology
    • Neuroscience

    Background:

    • The arachnoid membrane forms a critical component of the brain's protective layers.
    • Understanding its maturation is key to comprehending central nervous system development and barrier function.

    Purpose of the Study:

    • To investigate the ultrastructural development of junctional complexes within the chick embryo arachnoid membrane.
    • To characterize the morphological changes of desmosomes, gap junctions, and tight junctions during arachnoid maturation.

    Main Methods:

    • Electron microscopy utilizing thin sections and freeze-fracture replicas.
    • Detailed observation of junctional complex morphology at various developmental stages (14 days to hatching).

    Main Results:

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    • By 14 days, distinct inner and outer arachnoid zones showed desmosomes and varied gap junctions.
    • Tight junctions first appeared around 15-17 days, initially as single strands associated with gap junctions.
    • A mature, multi-layered tight junctional network, intricately related to gap junctions, was observed by hatching (21 days).

    Conclusions:

    • The chick embryo arachnoid membrane undergoes significant ultrastructural changes during development.
    • The sequential emergence and complex arrangement of junctional complexes, particularly tight junctions, highlight the maturation of the arachnoid barrier function.