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Related Experiment Videos

Brain damage, stress, and life span: an experimental study

D Wozniak, S Finger, H Blumenthal

    Journal of Gerontology
    |March 1, 1982
    PubMed
    Summary

    Stressors like cold and restraint temporarily increased corticosterone and caused gastric erosions in mice. However, stress exposure was linked to a higher incidence of reticulum cell sarcomas metastasizing to the lungs.

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    Area of Science:

    • Neuroscience
    • Immunology
    • Oncology

    Background:

    • Stress impacts physiological and pathological processes.
    • The relationship between stress, lifespan, and cancer requires further investigation.

    Purpose of the Study:

    • To investigate the effects of chronic stress and brain lesions on mouse lifespan and cause of death.
    • To examine the correlation between stress exposure and the development of specific cancers.

    Main Methods:

    • Mice underwent frontal pole transections or sham operations.
    • Animals were exposed to cold stress and/or cold + restraint stress.
    • Serum corticosterone levels and gastric erosions were measured.
    • Lifespan and cause of death were recorded and analyzed.

    Main Results:

    • Neither brain lesions nor cold stress affected lifespan.
    • Stressors temporarily elevated serum corticosterone and caused gastric erosions.
    • A significant correlation was found between stress and cause of death, primarily due to reticulum cell sarcomas metastasizing to the lung.

    Conclusions:

    • While stressors did not impact overall lifespan, they influenced physiological stress responses and cancer incidence.
    • Stress exposure is associated with an increased frequency of pulmonary tumors, specifically reticulum cell sarcomas.

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