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Related Experiment Videos

Abnormal and sphincter response in chronically constipated children

V A Loening-Baucke, M K Younoszai

    The Journal of Pediatrics
    |February 1, 1982
    PubMed
    Summary

    Children with chronic constipation often have weaker internal anal sphincters. This study found their sphincter resting tone and response to rectal distension were significantly lower, indicating a core functional issue.

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    Area of Science:

    • Pediatric Gastroenterology
    • Physiology
    • Colorectal Surgery

    Background:

    • Chronic constipation is a common pediatric issue.
    • Anal sphincter dysfunction is suspected in some cases.
    • Understanding underlying mechanisms is crucial for effective treatment.

    Purpose of the Study:

    • To investigate anal sphincter function in children with chronic constipation.
    • To compare sphincter function between constipated and healthy children.
    • To assess changes in function after treatment.

    Main Methods:

    • Strain gauge manometry was used to measure anal sphincter function.
    • Evaluated 116 constipated and 18 healthy children.
    • Assessed resting tone, motor activity, and reflex responses to rectal distension.

    Main Results:

    • Constipated children showed significantly lower mean anal resting tone (P < 0.001).
    • Internal anal sphincter motor activity and rectosphincteric reflex amplitude were reduced in constipated children (P < 0.001).
    • These abnormalities persisted even in recovered patients.

    Conclusions:

    • The primary issue in chronically constipated children appears to be an abnormal internal anal sphincter.
    • This sphincter is weaker and less responsive to rectal distension compared to nonconstipated children.
    • Findings suggest a persistent functional deficit in the internal anal sphincter.

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