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Related Experiment Videos

Cell surface antigen -- a study in bladder tumours

J N Kulkarni, M R Kamat, S G Gangal

    Journal of Surgical Oncology
    |January 1, 1982
    PubMed
    Summary

    Bladder tumors lacking A.B.O. (H) cell surface antigen indicate poor prognosis and metastasis. Preserving this antigen correlates with fewer recurrences and a longer tumor-free interval, suggesting its use as a biological marker.

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    BJU international·2002

    Area of Science:

    • Oncology
    • Immunohistochemistry
    • Urothelial Carcinomas

    Background:

    • Bladder cancer prognosis is often determined by stage and grade.
    • Identifying reliable biological markers for bladder cancer is crucial for predicting patient outcomes.

    Purpose of the Study:

    • To investigate the presence of A.B.O. (H) cell surface antigen in bladder tumors.
    • To correlate antigen expression with tumor stage, grade, recurrence, and metastasis.

    Main Methods:

    • Examined 30 bladder tumors of various stages and grades.
    • Utilized the specific red cell adherence (SCRA) technique to detect A.B.O. (H) antigen expression.

    Main Results:

    • Ten patients with stage A, grade I tumors retained the antigen.
    • All patients with high-stage (B, C, D) and high-grade tumors showed antigen absence.
    • Absence of antigen correlated with increased metastasis and poor prognosis.
    • Antigen presence was associated with fewer recurrences and longer tumor-free intervals.

    Conclusions:

    • A.B.O. (H) cell surface antigen expression is a potential prognostic marker in bladder cancer.
    • SCRA can serve as a valuable tool for assessing bladder tumor aggressiveness.
    • Routine SCRA testing may aid in early detection of aggressive disease and personalized treatment strategies.

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