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A structured program in BASIC for the analysis of peripheral nerve morphometry

A H Pullen

    Journal of Neuroscience Methods
    |January 1, 1982
    PubMed
    Summary
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    This study presents a flexible BASIC program for analyzing nerve fiber and axon diameters from electron micrographs. The system provides detailed morphometric analysis and statistical data for peripheral nerve investigations.

    Area of Science:

    • Neuroscience
    • Morphometry
    • Microscopy

    Background:

    • Accurate morphometric analysis of nerve fibers is crucial for understanding peripheral nerve structure and function.
    • Existing methods for analyzing nerve fiber and axon caliber can be time-consuming and require specialized equipment.

    Purpose of the Study:

    • To develop a flexible and efficient BASIC program for analyzing cross-sectional measurements of nerve fiber (D) and axon (d) caliber.
    • To provide a system capable of deriving myelin sheath thickness (2M) and other relevant parameters.
    • To facilitate detailed morphometric investigations of peripheral nerves.

    Main Methods:

    • Development of a BASIC program for the M.S.I. 6800 microprocessor.
    • Data input routines for manual measurements, computed values (M.O.P.), and digitized data (digitizer tablet).

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  • Sub-routines for deriving myelin sheath thickness (2M = D-d) and the d/D ratio ('g').
  • Analytical programs for frequency distributions, associated statistics, and relational analyses (D:d, d:2M, D:g).

    • Main Results:

    • The program successfully analyzes cross-sectional measurements of fiber (D) and axon (d) caliber.
    • Derived parameters include myelin sheath thickness (2M) and the d/D ratio ('g').
    • Analytical outputs include frequency distributions, statistics, and relationship analyses, offering comprehensive morphometric data.

    Conclusions:

    • The developed BASIC program offers a flexible and extensible system for morphometric investigations of peripheral nerves.
    • It efficiently processes various data inputs and provides detailed analytical outputs.
    • The system is suitable for a wide range of morphometric studies involving nerve structures.