Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Copper pathology (author's transl)]

B Mallet, J Romette, J D Di Costanzo

    La Nouvelle Presse Medicale
    |January 30, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Copper is vital for enzymes and homeostasis, involving metallothionein and ceruloplasmin. Genetic disorders like Wilson

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Registration in relation to eugenics.

    The Eugenics review·2011
    Same author

    The reform of vital statistics: Outline of a system of national registration.

    The Eugenics review·2011
    Same author

    The social problem group: The president's account of the society's next task.

    The Eugenics review·2011
    Same author

    [Urinary iodide analysis: critical study of the digestion method].

    Annales de biologie clinique·2004
    Same author

    Role of extracellular molecular chaperones in the folding of oxidized proteins. Refolding of colloidal thyroglobulin by protein disulfide isomerase and immunoglobulin heavy chain-binding protein.

    The Journal of biological chemistry·2001
    Same author

    Production of immunoreactive thyroglobulin C-terminal fragments during thyroid hormone synthesis.

    Endocrinology·2000
    Same journal

    [Forms of intra-erythrocytes asexual multiplication of P. falciparium. Production of monoclonal antibodies].

    La Nouvelle presse medicale·2016
    Same journal

    [Cutaneous systemic angiitis in hairy cell leukemia].

    La Nouvelle presse medicale·1982
    Same journal

    [Isolated late epilepsy as manifestation of glioblastoma. True negative tests with the scanner].

    La Nouvelle presse medicale·1982
    Same journal

    [Non-specific benign ulcer of the colon. Arguments favoring its ischemic origin].

    La Nouvelle presse medicale·1982
    Same journal

    [Relation between psychological stress and obstetrical complications. Preliminary data].

    La Nouvelle presse medicale·1982
    Same journal

    [Significance of a "flat" curve of oral hyperglycemia. Comparison with a test meal].

    La Nouvelle presse medicale·1982
    See all related articles

    Area of Science:

    • Biochemistry
    • Human Physiology
    • Molecular Biology

    Background:

    • Copper is an essential dietary mineral, acting as a cofactor for crucial enzymes like ceruloplasmin and superoxide dismutase.
    • Copper metabolism is intricate, with metallothionein playing a key role in intestinal absorption and hepatic regulation.
    • Metallothioneins and ceruloplasmin are vital for maintaining copper homeostasis in the body.

    Purpose of the Study:

    • To elucidate the complex mechanisms of copper metabolism and its role in human health.
    • To investigate the involvement of metallothionein and ceruloplasmin in copper homeostasis.
    • To explore the pathogenetic basis of copper-related disorders, including Wilson's disease and Menkes' disease.

    Main Methods:

    • Review of existing literature on copper metabolism and related genetic disorders.

    Related Experiment Videos

  • Analysis of the roles of metallothionein in copper absorption and distribution.
  • Examination of ceruloplasmin levels in relation to copper homeostasis.

    • Main Results:

    • Metallothionein facilitates copper transport in intestinal cells and hepatocytes, regulating absorption and storage.
    • Wilson's disease and Menkes' disease exhibit low ceruloplasmin and serum copper levels, despite differing pathologies.
    • Altered metallothionein avidity and impaired biliary excretion are implicated in Wilson's disease pathogenesis.
    • Reduced avidity of metallothioneins for copper may underlie Menkes' disease.

    Conclusions:

    • Metallothioneins and ceruloplasmin are indispensable for maintaining copper balance.
    • Dysregulation of copper metabolism, particularly involving metallothionein, leads to severe genetic disorders.
    • Further research is needed to fully understand the biochemical defects in Wilson's and Menkes' diseases.