Failure to obtain functional equivalence between dopamine receptor blockade and extinction: evidence supporting a...

The effects of pimozide were tested in a discrete trial paradigm. Following 8 days of continuous reinforcement training with a retractable bar, subjects were divided into 3 groups: Vehicle-Extinction; Pimozide-Extinction and Pimozide-Reinforcement. Pimozide rats received 1 mg/kg of drug 4 hours prior to test. On each of 3 test days reinforcement continued to be delivered on a continuous reinforcement schedule for the Pimozide-Reinforcement Group whereas it was no longer delivered for the other two groups. Each test day was separated by 4 drug-free days. The Pimozide-Reinforcement Group showed the least response suppression, followed by the Vehicle-Extinction and Pimozide-Extinction Groups. These results do not support the anhedonic hypothesis that dopamine containing neurons mediate reward processes and were interpreted within a sensory-motor conditioning framework.