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Particulate material in antihemophilic factor (AHF) concentrates
Transfusion
|September 1, 1978
Summary
Particulate material in antihemophilic factor (AHF) concentrates may be linked to microemboli. This material, composed of IgG and other proteins, is retained by a 40 mu filter, but its clinical significance requires further investigation.
Area of Science:
- Hematology
- Biochemistry
- Medical Devices
Background:
- Antihemophilic factor (AHF) concentrates are critical for treating hemophilia.
- The presence of noncellular particulate material in AHF concentrates has been noted.
- The composition and clinical relevance of this particulate material are not fully understood.
Purpose of the Study:
- To characterize the noncellular particulate material found in AHF concentrates.
- To investigate the potential clinical implications of this material, specifically regarding microemboli formation.
Main Methods:
- Utilized a 40 mu pore size screen filter to retain particulate matter from AHF concentrates.
- Analyzed the composition of the retained material using biochemical methods.
Main Results:
- Noncellular particulate material was effectively retained by the 40 mu filter.
- The material was identified to be composed partly of IgG, fibrinoprotein, and cold insoluble globulin.
- The exact clinical significance of this particulate material remains uncertain.
Conclusions:
- Particulate matter in AHF concentrates can be isolated using a 40 mu filter.
- The identified components (IgG, fibrinoprotein, cold insoluble globulin) suggest potential biological interactions.
- A possible association between this material and the formation of pulmonary and cerebral microemboli is hypothesized, warranting further clinical study.