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Glucose intolerance and nine-year mortality in Japanese men in Hawaii
Insights
Glucose intolerance significantly increases the risk of death from all causes, cardiovascular disease, and coronary heart disease in middle-aged Japanese-American men. This association persists even after accounting for other cardiovascular risk factors.
Area of Science:
- Endocrinology
- Epidemiology
- Cardiovascular Research
Background:
- Glucose intolerance is a condition characterized by elevated blood glucose levels.
- It is a precursor to type 2 diabetes and is associated with increased cardiovascular risk.
Purpose of the Study:
- To examine the relationship between glucose intolerance and nine-year mortality.
- To identify glucose intolerance as an independent risk factor for mortality in Japanese-American men.
Main Methods:
- A cohort study of approximately 8,000 Japanese-American men aged 45-68 years at baseline.
- Glucose intolerance defined by diabetes medication or 1-hour post-load serum glucose levels (>225 mg/dl).
- Mortality data analyzed for all causes, cardiovascular disease, coronary heart disease, and other causes over nine years.
Main Results:
- Men with glucose intolerance had significantly higher age-adjusted mortality rates from all causes, cardiovascular disease, and coronary heart disease.
- Glucose intolerance remained a significant risk factor for overall, cardiovascular, and coronary death in multivariate analysis.
- This significance persisted after adjusting for age, blood pressure, serum cholesterol, and body mass index.
Conclusions:
- Glucose intolerance is a significant independent predictor of mortality in middle-aged Japanese-American men.
- Early identification and management of glucose intolerance may be crucial for reducing cardiovascular and overall mortality.
- Further research into the mechanisms linking glucose intolerance and mortality is warranted.
Abstract:
The relationship between glucose intolerance and nine-year mortality was examined in a cohort of approximately 8,000 men of Japanese ancestry living in Hawaii who were 45 to 68 years of age at baseline examination. Age-adjusted mortality for death from all causes, cardiovascular disease, coronary heart disease and causes other than cardiovascular disease and cancer were significantly higher in men with glucose intolerance, defined by either medication for diabetes or 1-hour post-load serum glucose levels above the 90th percentile cut-point (225 mg/dl) at baseline examination, than in normoglycemic men. Although many cardiovascular risk factors were found to be associated with glucose intolerance, both post-load serum glucose level and medication for diabetes remained significant as risk factors for overall, cardiovascular and coronary death in multivariate logistic analysis in which confounding effects of age, blood pressure, serum cholesterol, body mass index and other important risk factors were taken into account.