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Periodic meningitis and familial Mediterranean fever

J Vilaseca, J Tor, J Guardia

    Archives of Internal Medicine
    |February 1, 1982
    PubMed

    Insights

    Familial Mediterranean fever can manifest as recurrent aseptic meningitis and nephrotic syndrome. Colchicine therapy effectively treated these symptoms, suggesting a link between Mollaret's syndrome and FMF.

    Area of Science:

    • Neurology
    • Rheumatology
    • Nephrology

    Background:

    • Recurrent aseptic lymphocytic meningitis, fever, and rash are key symptoms.
    • Nephrotic syndrome can develop, indicating renal involvement.

    Observation:

    • A 33-year-old male patient presented with a 13-year history of recurrent meningitis, fever, and rash.
    • Renal biopsy revealed amyloid deposits causing nephrotic syndrome.

    Findings:

    • Colchicine treatment led to the cessation of recurrent fever and meningitis episodes.
    • The patient's clinical presentation suggests an unusual manifestation of familial Mediterranean fever.

    Implications:

    • Aseptic periodic meningitis (Mollaret's syndrome) should be considered in the differential diagnosis of familial Mediterranean fever.
    • This case highlights the diverse clinical spectrum of FMF and the efficacy of colchicine in managing its varied manifestations.

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