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Updated: Aug 15, 2026
14:57
Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
Published on: March 23, 2011
Abstract:
In hippocampal slices of the rat maintained in vitro the addition of carbachol to the perfusion medium caused a depolarization accompanied by a conductance decrease and a block of inhibitory postsynaptic potentials in CAl pyramidal cells. During tetrodotoxin poisoning a smaller depolarization with conductance decrease was observed. Atropine blocked the effects of carbachol.
