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[Mycotic esophagitis - a contribution to its etiology]
Abstract:
Six cases of mycotic pseudomembrane inflammation of the esophagus formed 0.6% of all the necropsies within observed period. The basic disease was malignant tumour in 5 patients, non-tumorous blood disease in one. Culturally, yeast-like organisms of the genus Candida were proved in all cases. In three cases necrotizing and pseudomembrane inflammation of the larynx developed simultaneously. In the control group cultivation examination of the esophagus and larynx was made in 50 "at risk" patients (children, diabetics and oncologic patients) without any overt mycotic disease. A positive mycologic findings was from the esophagus in 60% from the larynx in 38%. In both localities the most frequent was Candida albicans, in isolated cases also conditionally pathogenic fungi of the genera, Saccharomyces and Torulopsis were detected. All these organisms apparently may spread from the digestive tract to the upper respiratory passages.
Insights
Mycotic pseudomembrane inflammation of the esophagus, often linked to underlying conditions like cancer, can affect the larynx. Candida species are frequently identified, suggesting potential spread from the digestive tract.
Area of Science:
- Medical Mycology
- Gastroenterology
- Otolaryngology
Context:
- Esophageal mycotic pseudomembrane inflammation is a rare but serious condition.
- The study investigated the prevalence and causative agents of esophageal and laryngeal mycosis.
- Underlying conditions such as malignancy and blood disorders were common in affected patients.
Purpose:
- To determine the incidence of mycotic pseudomembrane inflammation of the esophagus.
- To identify the fungal species involved in esophageal and laryngeal mycosis.
- To explore the potential pathway of fungal dissemination from the digestive tract to the upper respiratory passages.
Summary:
- Six cases of esophageal mycotic pseudomembrane inflammation were identified, representing 0.6% of necropsies.
- Candida species were consistently isolated from affected esophagi, with co-involvement of the larynx in some cases.
- A control group of at-risk patients showed high rates of fungal colonization in the esophagus (60%) and larynx (38%), predominantly Candida albicans.
Impact:
- Highlights the association between esophageal candidiasis and upper airway mycosis.
- Underscores the importance of considering fungal infections in patients with underlying diseases.
- Suggests the digestive tract as a reservoir for fungi that can affect the respiratory system.