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The cells in tonsillar crypts

A J Howie

    Clinical Otolaryngology and Allied Sciences
    |February 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Human tonsil crypts contain degenerating cells, indicating a primary defense role for the tonsil epithelium rather than the crypt lumen. This suggests epithelial cells act as the initial barrier against pathogens.

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    Area of Science:

    • Immunology
    • Cell Biology
    • Otolaryngology

    Background:

    • The palatine tonsils are key components of the human immune system, located in the oropharynx.
    • Their crypts are known to harbor a diverse range of cells and microbial populations.
    • Understanding the cellular dynamics within tonsil crypts is crucial for comprehending local immune responses.

    Purpose of the Study:

    • To investigate the cellular composition and condition of material within human palatine tonsil crypts.
    • To determine the origin and fate of non-epithelial cells found in the tonsil crypt lumen.
    • To elucidate the primary site of immune defense mechanisms within the tonsil.

    Main Methods:

    • Scanning and transmission electron microscopy were employed to analyze samples from 11 human palatine tonsils.

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  • Detailed ultrastructural examination of the material collected from the tonsil crypts.

    • Main Results:

    • The tonsil crypt material comprised desquamated epithelial cells, lymphocytes, mononuclear phagocytes, plasma cells, erythrocytes, neutrophil leucocytes, and mast cells.
    • A significant proportion of these cells were degenerating, accompanied by substantial cellular debris.
    • Non-epithelial cells likely entered the crypts by migrating through or being trapped within the sloughing superficial squamous epithelial cells.

    Conclusions:

    • Widespread cellular degeneration in the tonsil crypts suggests a mechanism for cell shedding and removal from the body.
    • The findings indicate that the tonsil's primary defense is located within the lining epithelium, not the crypt lumen.
    • The tonsil epithelium acts as the initial barrier, with cells potentially being eliminated after their function or entrapment within the crypts.