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Methods and approaches for assessing immunotoxicity: an overview

J H Dean, M I Luster, G A Boorman

    Environmental Health Perspectives
    |February 1, 1982
    PubMed
    Summary
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    The National Toxicology Program uses immune function assays to detect subtoxic chemical damage. These methods help assess toxicity and understand immunological injury mechanisms.

    Area of Science:

    • Toxicology
    • Immunology
    • Biochemistry

    Background:

    • The National Toxicology Program (NTP) aims to understand chemical toxicity's impact on the immune system.
    • Assessing immune function is crucial for identifying subtle, subtoxic effects of chemical exposures.
    • Existing methods require refinement for comprehensive immunotoxicity evaluation.

    Purpose of the Study:

    • To discuss the NTP's goals for immunological evaluation in toxicity assessment.
    • To propose immune function assays for detecting subtoxic cellular injury from chemical toxicants.
    • To present comprehensive screening and mechanistic panels for immunotoxicity assessment.

    Main Methods:

    • Utilizing a comprehensive screening panel of immune function and host resistance assays.

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  • Employing a second panel designed to define the mechanisms of immunological injury.
  • Applying an integrated approach for immunotoxicity assessment and methods selection.

    • Main Results:

    • Immune function assays can identify cellular injury at subtoxic levels.
    • The proposed panels provide a structured approach to immunotoxicity assessment.
    • Companion papers detail studies using these methods.

    Conclusions:

    • The presented assays and panels offer a robust framework for evaluating chemical immunotoxicity.
    • This approach aids in understanding both the extent and mechanism of immune system damage.
    • Further research in companion papers validates these assessment strategies.