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Treatment and prognosis of rectal prolapse in cystic fibrosis

R C Stern, R J Izant, T F Boat

    Gastroenterology
    |April 1, 1982
    PubMed

    Insights

    Rectal prolapse is a common early sign in cystic fibrosis patients, often resolving spontaneously or with enzyme therapy. Early diagnosis is key, and a sweat test is recommended for any child with rectal prolapse.

    Area of Science:

    • Pediatric Gastroenterology
    • Genetics
    • Surgical Pediatrics

    Background:

    • Rectal prolapse is a notable symptom in pediatric cystic fibrosis (CF) cases.
    • Physicians often overlook rectal prolapse as an early indicator of CF.

    Purpose of the Study:

    • To investigate the incidence and significance of rectal prolapse in cystic fibrosis patients.
    • To evaluate the relationship between rectal prolapse and CF diagnosis and treatment.

    Main Methods:

    • Retrospective analysis of 18.5% (112 of 605) cystic fibrosis patients with rectal prolapse.
    • Observation of prolapse onset relative to CF diagnosis and response to therapy.

    Main Results:

    • Rectal prolapse preceded CF diagnosis in 48 patients.
    • Prolapse often resolved with pancreatic enzyme replacement therapy post-diagnosis.
    • Many patients self-managed prolapse, with surgery rarely needed.
    • Spontaneous resolution occurred in some undiagnosed cases by age 3-5.

    Conclusions:

    • Rectal prolapse warrants consideration as an early sign of cystic fibrosis.
    • A sweat test is crucial for any child experiencing rectal prolapse.
    • Management strategies vary, with conservative approaches often effective.

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