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[Disseminated intravascular coagulation syndrome in sepsis in infants]
Vestnik Khirurgii Imeni I. I. Grekova
|September 1, 1978
Insights
Disseminated intravascular coagulation (DIC) was prevalent in children who died from sepsis. Pathological findings confirmed DIC in most fatal sepsis cases, though not in all severe local infections.
Area of Science:
- Pediatric pathology
- Infectious diseases
- Hematology
Context:
- Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection.
- Disseminated intravascular coagulation (DIC) is a serious condition that involves abnormal blood clotting throughout the body's small blood vessels.
Purpose:
- To investigate the occurrence and pathological evidence of disseminated intravascular coagulation (DIC) in children who died from sepsis.
- To correlate clinicopathological findings of DIC with sepsis and severe local purulent processes.
Summary:
- Autopsy findings revealed disseminated intravascular coagulation (DIC) in 40 out of 45 children who died from sepsis between 1974 and 1976.
- Histological evidence of DIC was present in 27 cases, often accompanied by characteristic clinical and laboratory signs.
- DIC was not identified in 10 children who succumbed to severe localized purulent infections, suggesting a distinct pathological process.
Impact:
- Highlights the significant role of DIC as a pathological complication in pediatric sepsis mortality.
- Provides insights into the differential diagnosis between sepsis-induced DIC and other severe infections.
- Emphasizes the importance of pathological examination in understanding the mechanisms of death in pediatric sepsis.
Abstract:
In 40 out of 45 children dead from sepsis in 1974--1976 the development of the syndrome of disseminated intravascular coagulation was proved on the grounds of the pathologic picture. In 27 cases histological changes were combined with characteristic clinico-laboratory manifestations of the syndrome. The latter was not found in 10 children who died of a severe local purulent process.