Influence of dosage form and administration route on the pharmacokinetic parameters of cefadroxil

A cross-over study was utilized to compare the pharmacokinetics of 500 mg cefadroxil administered intravenously and orally in solution, suspension, and in capsule form, and to calculate its bioavailability. The antibiotic was administered to four healthy volunteers on whom four experiments were carried out. Cefadroxil was determined in serum and in urine using a microbiologic plate diffusion method. Administered intravenously the antibiotic follows a two-compartment open kinetic model, whereas orally administered, its mode is that of a single-compartment model. There are no statistically significant differences between the parameters defining the elimination of the antibiotic in the four groups studied.