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Canine cutaneous lymphoma

P J McKeever, C B Grindem, J B Stevens

    Journal of the American Veterinary Medical Association
    |March 1, 1982
    PubMed
    Summary
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    This study describes canine cutaneous lymphoma (mycosis fungoides) in 13 dogs, noting skin lesions and lymph node enlargement. While cytotoxic drugs improved skin signs, they did not prevent disease spread.

    Area of Science:

    • Veterinary Dermatology
    • Canine Oncology
    • Dermatopathology

    Background:

    • Cutaneous lymphoma, specifically mycosis fungoides, is a significant neoplastic condition affecting dogs.
    • Early diagnosis and understanding disease progression are crucial for effective management.
    • Clinical signs can be variable, making diagnosis challenging.

    Purpose of the Study:

    • To characterize the clinical and pathological features of mycosis fungoides in a cohort of dogs.
    • To evaluate the response of canine mycosis fungoides to cytotoxic drug therapy.

    Main Methods:

    • Diagnosis was confirmed through multiple biopsies of cutaneous lesions.
    • Clinical staging included assessment of skin lesions and lymph node size.
    • Treatment involved cytotoxic drugs in a subset of affected dogs.

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    Main Results:

    • Thirteen dogs were diagnosed with mycosis fungoides, presenting initially with trunk erythema and alopecia.
    • Progressive disease led to severe scaling, pruritus, and nodule formation.
    • Lymphadenopathy developed as the disease advanced; cytotoxic therapy resulted in marked skin improvement in 3/4 dogs but did not halt extra-cutaneous spread.

    Conclusions:

    • Canine mycosis fungoides follows a progressive course with characteristic dermatological and systemic manifestations.
    • Cytotoxic chemotherapy can palliate skin lesions but does not offer a cure for advanced disease.
    • Further research into novel therapeutic strategies is warranted for canine cutaneous lymphoma.