Enzyme-linked immunosorbent assay for the diagnosis of recent rubella infection

This paper presents further evidence of the sensitivity and reproducibility of ELISA for the detection of rubella antibody. This test can also be extended to include the diagnosis of recent rubella infections once the index of significance has been computed based on the estimated ELISA ratio of absorbance between the acute and convalescent serum samples. There is a greater than 90% agreement when compared to the results obtained by the haemagglutination-inhibition test. It should be further evaluated for rubella using purified rubella antigen to increase sensitivity and reproducibility.