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Related Experiment Videos

Clostridium difficile toxin in asymptomatic neonates

S T Donta, M G Myers

    The Journal of Pediatrics
    |March 1, 1982
    PubMed
    Summary

    Clostridium difficile toxin is common in newborns, especially in the NICU. Antibiotic exposure significantly increases toxin carriage for months, even without illness.

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    Area of Science:

    • Microbiology
    • Neonatal Medicine
    • Pediatric Infectious Diseases

    Background:

    • Clostridium difficile is an opportunistic pathogen.
    • Neonates, particularly those in intensive care, may be susceptible to colonization.
    • Understanding transmission and carriage in newborns is crucial for infection control.

    Purpose of the Study:

    • To investigate the prevalence of Clostridium difficile toxin in neonates.
    • To identify risk factors associated with toxin carriage in this population.
    • To examine the impact of antibiotic exposure on toxin detection.

    Main Methods:

    • Fecal samples were collected from normal newborns and neonates in the intensive care unit (NICU).
    • Samples were tested for the presence of Clostridium difficile toxin.
    • Infant delivery method, feeding practices, and antibiotic exposure history were recorded.

    Main Results:

    • Clostridium difficile toxin was detected in 10.5% of normal newborns and 55% of NICU neonates.
    • Vaginal delivery and breast-feeding were associated with higher toxin carriage rates.
    • Antibiotic exposure led to toxin detection in 85% of infants for at least two months post-therapy.

    Conclusions:

    • Clostridium difficile toxin carriage is prevalent in neonates, particularly in the NICU.
    • Delivery mode and feeding practices may influence colonization.
    • Antibiotic use is a significant risk factor for prolonged Clostridium difficile toxin carriage in infants.

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