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Unusual radiological changes associated with probable Bartter's syndrome

B F Jones, R S Nanra

    The Journal of Urology
    |February 1, 1982
    PubMed
    Summary

    Two cases with Bartter's syndrome showed significant kidney abnormalities, including caliceal distortion and cortical loss, without typical causes like reflux or hypokalemia. The exact reason for these radiological changes remains unclear.

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    Area of Science:

    • Nephrology
    • Radiology
    • Medical Genetics

    Background:

    • Bartter's syndrome is a rare inherited renal tubulopathy characterized by electrolyte disturbances.
    • Understanding the spectrum of Bartter's syndrome manifestations is crucial for diagnosis and management.

    Observation:

    • Two patients presented with features suggestive of Bartter's syndrome.
    • Both patients exhibited significant radiological abnormalities in the kidneys, including distorted caliceal patterns and medullary cavities.
    • These renal changes occurred in the absence of vesicoureteral reflux.

    Findings:

    • Despite marked radiological changes, glomerular filtration rate was preserved in both patients.
    • The observed renal pathology was not attributed to known organic renal diseases.

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  • Hypokalemia did not appear to be the cause of the radiological findings.

    • Implications:

    • The study highlights unusual radiological presentations associated with Bartter's syndrome.
    • The pathogenesis of these specific renal changes in the context of Bartter's syndrome requires further investigation.
    • This case report may prompt consideration of Bartter's syndrome in patients with unexplained renal radiological abnormalities.