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Post-mating non-infectious hydrometra in BALB/c: Bom mice
Laboratory Animals
|January 1, 1982
Summary
Post-mating hydrometra and hydrovagina caused vulvar closure and uterine secretions in BALB/c:Bom mice. This non-infectious condition rendered mice infertile but did not affect overall health or transmissibility.
Area of Science:
- Veterinary Pathology
- Reproductive Biology in Mammals
- Murine Models in Research
Background:
- Non-infectious hydrometra and hydrovagina are rare conditions.
- These conditions can lead to reproductive failure in female mammals.
- The aetiology of post-mating hydrometra and hydrovagina remains largely unknown.
Purpose of the Study:
- To document and characterize a case of post-mating hydrometra and hydrovagina in BALB/c:Bom mice.
- To investigate the clinical presentation and potential causes of this condition.
- To assess the impact on reproductive capability and overall health.
Main Methods:
- Observation of clinical signs during a breeding experiment involving BALB/c:Bom mice.
- Gross pathological examination of affected mice.
- Assessment of breeding performance and general health parameters.
Main Results:
- A 1% incidence of vulvar closure, hydrometra, and hydrovagina was observed post-mating.
- Affected mice exhibited perineal swelling but maintained normal body weight and clinical health.
- Uterine and vaginal secretions accumulated under high pressure.
- Reproductive capability was completely abolished in affected individuals.
- The condition was non-infectious and not transmissible to other mice.
Conclusions:
- Post-mating hydrometra and hydrovagina in BALB/c:Bom mice is a non-infectious, sporadic condition.
- This condition leads to infertility due to vulvar obstruction and uterine/vaginal distension.
- Further research is needed to elucidate the specific aetiology of this reproductive anomaly.