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[Acute arsenious hydride intoxication. Four cases (author's transl)]
La Nouvelle Presse Medicale
|February 6, 1982
Summary
Workers exposed to arsenious hydride (AsH3) fumes developed acute haemolysis and subsequent neurological issues. Prompt treatment with blood exchange and dialysis was crucial for recovery.
Area of Science:
- Toxicology
- Occupational Health
- Environmental Medicine
Context:
- Accidental exposure to arsenious hydride (AsH3) fumes during zinc furnace repair.
- Four workers presented with acute intravascular haemolysis within hours of exposure.
Purpose:
- To report a case series of acute arsenious hydride poisoning.
- To describe the clinical manifestations and management of AsH3 toxicity.
- To monitor arsenic levels during treatment.
Summary:
- Patients underwent exsanguino-transfusion (8.2–10.2 L) and haemodialysis.
- Two patients resumed diuresis during transfusion; others required repeated haemodialysis.
- Mild megaloblastic anaemia and polyneuritis developed, followed by gradual regression.
Impact:
- Highlights the severe haemolytic and neurotoxic effects of AsH3.
- Emphasizes the importance of timely and aggressive medical intervention.
- Provides data on arsenic levels during treatment for AsH3 poisoning.