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Polymyalgia rheumatica syndrome

L Knudsen, G Christensen, L Krohn

    Scandinavian Journal of Rheumatology
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Polymyalgia rheumatica syndrome (PMR-S) often requires long-term systemic glucocorticoids, but depot steroids may offer an alternative for uncomplicated cases. This approach could reduce steroid side effects and prolonged treatment duration.

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    Area of Science:

    • Rheumatology
    • Internal Medicine

    Background:

    • Polymyalgia rheumatica syndrome (PMR-S) is a common inflammatory condition.
    • Giant cell arteritis (GCA) can be associated with PMR-S.
    • Treatment often involves systemic glucocorticoids, carrying potential side effects.

    Purpose of the Study:

    • To evaluate the long-term outcomes of polymyalgia rheumatica syndrome (PMR-S) management.
    • To assess the efficacy and safety of systemic glucocorticoids versus depot steroids.
    • To discuss diagnostic criteria and treatment recommendations for PMR-S and GCA.

    Main Methods:

    • Retrospective analysis of 80 patients diagnosed with polymyalgia rheumatica syndrome (PMR-S).
    • Comparison of spontaneous remission rates, treatment durations, and side effect profiles.

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  • Review of diagnostic criteria and clinical management strategies.

    • Main Results:

    • 14% of PMR-S patients achieved spontaneous remission within one year.
    • Systemic glucocorticoids were used for an average of 30 months in 69 patients.
    • Seven patients experienced severe side effects, including osteoporosis and spinal compression, from systemic steroids.

    Conclusions:

    • Systemic glucocorticoids are essential for PMR-S with suspected GCA or ocular involvement.
    • Repeated depot steroid injections are recommended for uncomplicated PMR-S to minimize side effects.
    • Depot steroids may help manage recurrences and reduce prolonged systemic steroid use.