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Liver failure

L M Flint

The Surgical Clinics of North America

|February 1, 1982

Summary

This summary is machine-generated.

Post-injury hepatic failure often presents as cholestatic jaundice. Sepsis is the primary cause, necessitating aggressive infection control and potentially exploratory laparotomy for improved patient survival.

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Area of Science:

Hepatology
Trauma Surgery
Infectious Disease

Background:

Hepatic failure post-injury typically presents as cholestatic jaundice.
This differs from hepatic failure seen in alcoholic or post-hepatitic patients.
Sepsis is the leading cause of death in post-traumatic organ failure.

Purpose of the Study:

To investigate the etiology and management of hepatic failure following injury.
To highlight the role of sepsis in post-traumatic hepatic failure.
To evaluate the efficacy of aggressive infection control and surgical intervention.

Main Methods:

Review of patients experiencing hepatic failure after trauma.
Identification of sepsis as the primary etiological factor.

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Emphasis on prompt localization and eradication of infected foci.

Assessment of exploratory laparotomy as a diagnostic and therapeutic tool.

Main Results:

Sepsis is the predominant cause of hepatic failure in trauma patients.
Aggressive management of infection is crucial for treatment.
Exploratory laparotomy demonstrated a 50% improvement and survival rate in affected patients.

Conclusions:

Hepatic failure post-injury is frequently sepsis-induced.
Early and aggressive source control of infection is paramount.
Exploratory laparotomy is a vital intervention with significant survival benefits.