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A delayed transfusion reaction caused by anti-K6
Transfusion
|January 1, 1982
Summary
A delayed transfusion reaction was caused by the antibody anti-K6. This antibody was identified in a patient
Area of Science:
- Immunology
- Transfusion Medicine
- Hematology
Background:
- Delayed hemolytic transfusion reactions (DHTRs) can occur following red blood cell transfusions.
- Antibody identification is crucial for diagnosing and managing transfusion reactions.
Observation:
- A 42-year-old female experienced hemolysis 23 days post-transfusion.
- The patient had received three units of red blood cells for gastrointestinal bleeding.
Findings:
- Anti-K6 was identified in the patient's serum and red blood cell eluate.
- One transfused red blood cell unit was positive for the K:6 antigen, confirming the antibody-antigen match.
Implications:
- This case highlights anti-K6 as a clinically significant antibody causing delayed transfusion reactions.
- Accurate antibody screening and identification are vital for preventing transfusion-related hemolysis.