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Zn and Cu content in human cancellous bone

R Lappalainen, M Knuuttila, S Lammi

    Acta Orthopaedica Scandinavica
    |February 1, 1982
    PubMed
    Summary

    Bone mineral composition, including fluoride and copper, is crucial for bone strength, not significantly differing between normal and osteoporotic bone. These trace elements are key indicators of bone health.

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    Area of Science:

    • Orthopedics
    • Biochemistry
    • Materials Science

    Background:

    • Osteoporosis is a significant health concern characterized by reduced bone strength.
    • Bone mineral composition plays a critical role in determining bone mechanical properties.
    • Understanding the elemental composition of bone is vital for diagnosing and treating bone diseases.

    Purpose of the Study:

    • To investigate the relationship between elemental concentrations and bone mechanical properties in cancellous bone.
    • To identify key elements influencing bone strength and density.
    • To compare bone mineral status in individuals with normal bone and those with osteoporosis.

    Main Methods:

    • Autopsy-derived cancellous bone samples from 88 normal and 50 osteoporotic individuals.
    • Measurement of bone density (gamma-ray attenuation) and compressive strength (strain transducer).
    • Quantification of elemental concentrations (Ca, Mg, Cd, Co, Cu, Mn, Ni, Li, Pb, Sr, Zn, F) using atomic absorption spectrophotometry and ion-selective electrodes.
    • Statistical analysis using linear multiple regression.

    Main Results:

    • Fluoride (F) concentration explained 16.1% and Copper (Cu) concentration explained 13.7% of the variance in bone properties.
    • Manganese (Mn) concentration contributed an additional 8.5%.
    • Zinc (Zn) concentration (20.1%) was as significant as the combined contribution of Calcium (Ca), Mn, Strontium (Sr), and Cobalt (Co).
    • No significant differences in elemental concentrations were observed between normal and osteoporotic bone samples.
    • Age and sex did not significantly impact Zn and Cu concentrations.

    Conclusions:

    • Bone mineral composition, particularly concentrations of F, Cu, and Mn, significantly influences bone mechanical properties.
    • Trace elements are important indicators of bone quality, even in the absence of significant differences between normal and osteoporotic bone.
    • Further research into the role of specific elements in bone health is warranted.

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