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Bleeding time and scoliosis
Insights
This study found that individuals with scoliosis, particularly females with idiopathic scoliosis, exhibit prolonged bleeding times. These findings suggest collagen abnormalities contribute to various scoliosis types.
Area of Science:
- Biochemistry
- Orthopedics
- Hematology
Background:
- Collagen abnormalities are implicated in idiopathic scoliosis.
- A correlation exists between collagen's platelet aggregating power and bleeding time in scoliosis patients.
Purpose of the Study:
- To investigate bleeding time in patients with different types of scoliosis.
- To further explore the role of collagen abnormalities in scoliosis etiology.
Main Methods:
- Bleeding time was measured in 195 scoliosis cases and 318 controls.
- Patients were categorized into idiopathic, paralytic, and congenital scoliosis groups.
Main Results:
- Females, especially those with idiopathic scoliosis, showed significantly longer bleeding times.
- Paralytic scoliosis patients also had prolonged bleeding times compared to controls.
- Congenital scoliosis patients did not show significant differences from controls.
Conclusions:
- Prolonged bleeding time is associated with idiopathic and paralytic scoliosis.
- These results support the involvement of collagen abnormalities in the pathogenesis of various scoliosis forms.
- Bleeding time in idiopathic scoliosis was not influenced by age or curve severity.
Abstract:
Collagen abnormalities in idiopathic scoliosis are on record. Since there is a correlation between the platelet aggregating power of the collagen and the bleeding time in patients with scoliosis, the bleeding time was studied in 195 cases with scoliosis and in 318 controls. The bleeding time was longer in the females, especially in those with idiopathic scoliosis (n = 149). Patients with paralytic scoliosis (n = 5) also had a significantly longer bleeding time than non-scoliotic controls. The patients with congenital scoliosis (n = 13) did not differ significantly from the controls or from patients with idiopathic scoliosis. The bleeding time in idiopathic scoliosis did not vary with age or magnitude of the scoliosis. Our data support the view that collagen abnormalities play a role not only in the aetiology of idiopathic scoliosis, but also in other forms of scoliosis.