[Lipoproteins and fatty acids--hyperlipoproteinemia and arteriosclerosis]

At first on the basis of literature a short description of the interrelations between lipoprotein metabolism and fatty acid metabolism as well as hyperlipoproteinaemia on the one hand and arteriosclerotic-degenerative diseases of the coronary vessels on the other is given. Finally, the findings of gas-chromatographic analyses of the patterns of fatty acids of the cholesterol ester and triglyceride fractions of the serum of 252 patients with primary hyperlipoproteinaemia are represented. In contrast to persons with healthy metabolism increase of the proportions per cent of palmitic acid, stearic acid, palmitoleic acid, oleic acid, and eikosatrienic acid was shown and decrease of those ones of linoleic acid, linolenic acid, arachidonic acid, and eikosapentaic acid in the cholesterol ester fractions in hyperlipoproteinaemia type IIa and IIb and in the triglyceride fractions in hyperlipoproteinaemia type IIb and IV. The shifts within the patterns of fatty acids in hyperlipoproteinaemia are an expression of an atherogenic risk. Disturbances of the hepatogenic synthesis of fatty acids and oxydation of fatty acids, increased reesterification from the depot fat of mobilised fatty acids as well as a partially increased LCAT-activity are causally discussed.