Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A pattern for gastric emptying in mice

M Moretó, L Guzmán, A Díez

    The American Journal of Physiology
    |April 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Gastric emptying in mice was faster in lighter individuals. A hyperbolic model best described the emptying rate, with 50% emptied in under 5 minutes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Synthesis and <i>in vitro</i> antitumor evaluation of novel 3,4-dihydropyrimidinone-vorinostat hybrids against gastric and breast cancer cell lines.

    RSC advances·2026
    Same author

    Measurement of elastic properties of optical fibers under hydrogen and deuterium diffusion by forward-stimulated Brillouin scattering.

    Optics express·2026
    Same author

    Systematic study of a thulium-doped all-polarization maintaining modelocked fiber laser from a low to high fundamental repetition rate.

    Optics express·2025
    Same author

    Synthesis of novel fatty acid 3,4-dihydropyrimidin-2-(1<i>H</i>)-one and antitumoral activity against breast and gastric cancer cells.

    RSC advances·2024
    Same author

    Strain and temperature measurement discrimination with forward Brillouin scattering in optical fibers.

    Optics express·2022
    Same author

    High accuracy measurement of Poisson's ratio of optical fibers and its temperature dependence using forward-stimulated Brillouin scattering.

    Optics express·2022
    Same journal

    Blood coagulation in fish.

    The American journal of physiology·2011
    Same journal

    Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

    The American journal of physiology·2010
    Same journal

    The inactivation of placental toxin by human serum.

    The American journal of physiology·2010
    Same journal

    Adrenal function following ovariectomy in the rat.

    The American journal of physiology·2010
    Same journal

    Capillary permeability; perfusion of frog and guinea pig hind limbs.

    The American journal of physiology·2010
    Same journal

    Evaluation of protective measures against sunburn.

    The American journal of physiology·2010
    See all related articles

    Area of Science:

    • Pharmacology
    • Physiology
    • Biomedical Science

    Background:

    • Gastric emptying is a crucial physiological process influencing drug absorption and nutrient bioavailability.
    • Understanding gastric emptying kinetics is essential for optimizing drug delivery and therapeutic outcomes.

    Purpose of the Study:

    • To investigate the gastric emptying rates in CD-1 mice using a nonabsorbable test meal.
    • To mathematically model the gastric emptying process and identify the best-fitting kinetic equation.
    • To assess the influence of body weight and sex on gastric emptying in mice.

    Main Methods:

    • CD-1 mice (15-30 g) were administered a radioactive barium sulfate test meal in methylcellulose.
    • Gastric content was measured at 1, 2, 5, and 10 minutes post-administration.

    Related Experiment Videos

  • Data were fitted to exponential, hyperbolic, and parabolic equations to model emptying kinetics.

    • Main Results:

    • Initial gastric emptying rates were significantly higher in mice weighing 15-20 g.
    • In all groups, 50% of the test meal was emptied within 5 minutes.
    • A hyperbolic model provided a closer fit to the gastric emptying data compared to exponential or parabolic models.

    Conclusions:

    • Body weight influences gastric emptying rates in CD-1 mice, with lighter mice exhibiting faster emptying.
    • The hyperbolic model accurately describes the gastric emptying kinetics in this study.
    • No significant sex differences in gastric emptying were observed.