Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Midazolam in paediatric anaesthesia

W H Cole

    Anaesthesia and Intensive Care
    |February 1, 1982
    PubMed
    Summary

    Midazolam is a safe and effective anesthetic induction agent for children over 8 years old, acting faster than in adults. It offers advantages over diazepam due to its water solubility and ease of administration.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Nutritional problems and operability in the aged.

    Journal of the American Geriatrics Society·2014
    Same author

    Surgical treatment of peptic ulcer.

    Bulletin. Chicago Medical Society·2010
    Same author

    Intraperitoneal administration of succinylsulfathiazole and phthalylsulfathiazole; their use in the prophylaxis and treatment of peritonitis.

    Archives of surgery (Chicago, Ill. : 1920)·2010
    Same author

    Strictures of the common duct.

    Surgery, gynecology & obstetrics·2010
    Same author

    The technic of thyroidectomy.

    The Surgical clinics of North America·2010
    Same author

    Problems in Operability.

    The Ulster medical journal·2010

    Area of Science:

    • Anesthesiology
    • Pediatric Medicine
    • Pharmacology

    Background:

    • Intravenous midazolam is used for anesthesia induction.
    • Diazepam is a comparable anesthetic agent.

    Purpose of the Study:

    • To evaluate the efficacy and safety of midazolam for anesthesia induction in children over 8 years old.
    • To compare midazolam's effects with diazepam in pediatric patients.

    Main Methods:

    • A randomized clinical trial involving 100 children over 8 years old.
    • Intravenous midazolam was administered for anesthesia induction.
    • A control group received diazepam for anesthesia induction.

    Main Results:

    • Midazolam demonstrated similar actions to diazepam in children.
    • Midazolam exhibited a faster onset of action in children compared to adults.
    • Circulatory, respiratory effects, and postoperative amnesia incidence were comparable to adult data.
    • Postoperative vomiting occurred in 1% in the recovery room and 32% over two days.
    • No adverse effects were noted in laboratory investigations.

    Conclusions:

    • Midazolam is a satisfactory induction agent for pediatric anesthesia.
    • Its water solubility and safe injection without dilution present a significant advantage over diazepam.

    Related Experiment Videos